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1 · TopMed
2 · Step by step: towards a better understanding of the genetic
3 · New insights into the genetic etiology of Alzheimer’s disease and
4 · New insights into the genetic etiology of Alzheimer's disease and
5 · Molecular determinants of Alzheimer's disease and cognitive
6 · Genetics of Alzheimer's disease: where we are, and where we
7 · Céline Bellenguez
8 · Associationof MGMT and BIN1 geneswithAlzheimer’sdisease

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Published: 04 April 2022. New insights into the genetic etiology of Alzheimer’s disease and .

Céline Bellenguez 1 , Benjamin Grenier-Boley 1 , Jean-Charles Lambert 2. Affiliations. 1 Univ. .

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In the September 9 JAMA Neurology, scientists led by Michael Belloy, .Bellenguez, Céline ; Küçükali, Fahri ; Jansen, Iris E. et al. / New insights into the genetic .

Céline Bellenguez. Molecular Psychiatry 28, 2716–2727 (2023) Cite this article. .Our project aims to characterize the genetic determinants of neurodegenerative diseases and .Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias .

Céline Bellenguez. EADB. Inserm,InstitutPasteurdeLille,Lille,France. Abstract. lowing quality .

Email:[email protected] REFERENCES 1. Chung J, Das A, Sun X, et al. .Bellenguez, Céline ; Küçükali, Fahri ; Jansen, Iris E. et al. / New insights into the genetic .

Published: 04 April 2022. New insights into the genetic etiology of Alzheimer’s disease and related dementias. Céline Bellenguez, Fahri Küçükali, Iris E. Jansen, Luca Kleineidam, Sonia.Céline Bellenguez 1 , Benjamin Grenier-Boley 1 , Jean-Charles Lambert 2. Affiliations. 1 Univ. Lille, Inserm, Institut Pasteur de Lille, CHU Lille, U1167 - Labex DISTALZ - RID-AGE - Risk Factors and Molecular Determinants of Aging-Related Diseases, F-59000 Lille, France. In the September 9 JAMA Neurology, scientists led by Michael Belloy, Washington University in St. Louis, report four common and two rare variants on the X chromosome that associate with AD. This follows an XWAS uploaded to medRxiv May 3, in which an international group led by Céline Bellenguez, University of Lille, France, identified four .

Bellenguez, Céline ; Küçükali, Fahri ; Jansen, Iris E. et al. / New insights into the genetic etiology of Alzheimer’s disease and related dementias. In: Nature Genetics. 2022 ; Vol. 54, No. 4. pp. 412-436. Céline Bellenguez. Molecular Psychiatry 28, 2716–2727 (2023) Cite this article. 10k Accesses. 22 Citations. 32 Altmetric. Metrics. Abstract. Alzheimer’s disease (AD) is considered to have a.Our project aims to characterize the genetic determinants of neurodegenerative diseases and of Alzheimer’s disease in particular, the leading cause of dementia worldwide, and then to understand their implications in pathophysiological processes. To do this, we are developing high-throughput genomics approaches (genome-wide association studies .

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'pro ..Céline Bellenguez. EADB. Inserm,InstitutPasteurdeLille,Lille,France. Abstract. lowing quality control, including 8,633,349 common variants (minor allele frequency (MAF) above 1%), and 1,324,211 low frequency variants (MAF range between 0.5% and 1%). We identified 57 loci with at least suggestive evidence (P 1 10−. ×.Email:[email protected] REFERENCES 1. Chung J, Das A, Sun X, et al. Genome-wide association and multi-omics studies identify MGMT as a novel risk gene for Alzheimer’s disease amongwomen.Alzheimer’sDement.2023;19:896-908.doi:10.1002/alz. 12719 2. BellenguezC, KüçükaliF, Jansen IE, et al. New insightsintothe geneticBellenguez, Céline ; Küçükali, Fahri ; Jansen, Iris E. et al. / New insights into the genetic etiology of Alzheimer’s disease and related dementias. In: Nature Genetics. 2022 ; Vol. 54, No. 4. pp. 412-436.

Published: 04 April 2022. New insights into the genetic etiology of Alzheimer’s disease and related dementias. Céline Bellenguez, Fahri Küçükali, Iris E. Jansen, Luca Kleineidam, Sonia.Céline Bellenguez 1 , Benjamin Grenier-Boley 1 , Jean-Charles Lambert 2. Affiliations. 1 Univ. Lille, Inserm, Institut Pasteur de Lille, CHU Lille, U1167 - Labex DISTALZ - RID-AGE - Risk Factors and Molecular Determinants of Aging-Related Diseases, F-59000 Lille, France. In the September 9 JAMA Neurology, scientists led by Michael Belloy, Washington University in St. Louis, report four common and two rare variants on the X chromosome that associate with AD. This follows an XWAS uploaded to medRxiv May 3, in which an international group led by Céline Bellenguez, University of Lille, France, identified four .

Bellenguez, Céline ; Küçükali, Fahri ; Jansen, Iris E. et al. / New insights into the genetic etiology of Alzheimer’s disease and related dementias. In: Nature Genetics. 2022 ; Vol. 54, No. 4. pp. 412-436.

Céline Bellenguez. Molecular Psychiatry 28, 2716–2727 (2023) Cite this article. 10k Accesses. 22 Citations. 32 Altmetric. Metrics. Abstract. Alzheimer’s disease (AD) is considered to have a.Our project aims to characterize the genetic determinants of neurodegenerative diseases and of Alzheimer’s disease in particular, the leading cause of dementia worldwide, and then to understand their implications in pathophysiological processes. To do this, we are developing high-throughput genomics approaches (genome-wide association studies .Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'pro ..Céline Bellenguez. EADB. Inserm,InstitutPasteurdeLille,Lille,France. Abstract. lowing quality control, including 8,633,349 common variants (minor allele frequency (MAF) above 1%), and 1,324,211 low frequency variants (MAF range between 0.5% and 1%). We identified 57 loci with at least suggestive evidence (P 1 10−. ×.

Email:[email protected] REFERENCES 1. Chung J, Das A, Sun X, et al. Genome-wide association and multi-omics studies identify MGMT as a novel risk gene for Alzheimer’s disease amongwomen.Alzheimer’sDement.2023;19:896-908.doi:10.1002/alz. 12719 2. BellenguezC, KüçükaliF, Jansen IE, et al. New insightsintothe genetic

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